or Satan), The Wafer becomes most effective in the Womb and beyond where enemies all deal a whole heart of damage, The Wafer causes the Sharp Plug item to only cost 1/2 a heart per use, Has no effect with the Keeper - there's no such thing as half a coin health point, * angel room pool, god room pool, angel room item, item room, treasure room, item room pool, If a pushed enemy hits a rock or wall forcefully enough, they take 10 damage, UNLOCK: Unlock this item by destroying 100 poops, * normal beggar pool, normal judgement pool, coin beggar pool, coin judgement pool, item room, Spindown Dice itself will be rerolled into Anima Sola, while Hypercoagulation rerolls into it. REPENTANCE - Dark Prince's Crown now grants more of an increase in rate of fire, and the bonus now breaks the soft tears cap. Spindown Dice is the only dice item that cannot be copied by the D Infinity. in Isaac? Random tear effect for every room. Unlocked from Challenge #25 - Have a Heart, Feels like I'm walking on sunshine! This doesn't work with The Lost characters, While in a room with enemies, red cracks will appear on the floor in random locations, Walking over the crack spawns a white soul familiar, that launches itself into the nearest enemy, exploding and dealing double your tear damage to everything near it, Cracks will keep appearing but only one can exist in the room at a time, UNLOCK: Unlock this item by defeating challenge #38 (Baptism by Fire), While held, this item spawns a familiar that can be moved around using the arrow keys and deals 1.5 damage per tick to any enemies it touches, When activated, you teleport, swapping places with wherever Stitches was positioned, Teleporting next to fires will extinguish them (including blue fires) and on top of shopkeepers will destroy them (gives +10% devil/angel room chance as normal), If used while stitches is on top of an enemy, it can be used to telefrag enemies, dealing x3.5 your damage + 40, Can be used to enter/exit Curse Rooms for free by teleporting infront of the door while holding the direction key to move in immediately. Placing a bomb while pressing a fire button will fire an explosive rocket in that direction, Placing a bomb while standing still will place a regular bomb, Upon use, spawns a flame familiar that fires spectral tears and deals contact damage to enemies. Based on the Steam Workshop mod created by Niro, A familiar with a charged attack, that spawns a line of creep on the floor which damages enemies that walk over it, The familiar and its creep will change randomly when Isaac uses a pill, Possible creep types include green (deals damage), black (slows enemies), red (deals damage, forms a line with a larger puddle), yellow (deals damage, forms a short-range cone) and white (slows enemies, forms a ring), Added as part of the Afterbirth+ Booster Pack #5. UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby. - Speeds up all enemies for the rest of the room. The spear occasionally inflicts fear on enemies it damages. UNLOCK: Unlock this item by defeating Lil Horn 20 times, When picked up, gives Isaac a random familiar which has a random sprite and tear effect, The familiar will be fully randomized again upon entering the next floor, The appearance is chosen from a random co-op baby sprite, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ashkait and Scayze, A familiar that will transform into another random familiar every 10 seconds, copying their behaviour and effect, Can be any other familiar, including (but not limited to) Lil Brimstone, Bob's Brain, BBF, Meatboy, Rotten Baby, Familiars appear as a white Delirium version of the original, This item gives you 1 bar of charge on your active item for every 15 enemies you kill, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Ashkait and Scayze, UNLOCK: Unlock this item by picking up any 3 of these items in a single run: 9 Volt, The Battery, Car Battery, AAA Battery, Watch Battery, When used, the coupon causes one random item in the shop to become free, While held, guarantees a random item or pickup from the shop to be half price, The effect of this item also works in Devil Rooms, allowing you to take one random item for free, Added as part of the Afterbirth+ Booster Pack #2 and based on the Steam Workshop mod created by Plumbo, *, paper, square, green, pink, white, barcode, letter, postcard, An active that causes all enemy tears to be held in place and then thrown back away from Isaac for a period of 3 seconds, The aura from this item will repel nearby enemies, Added as part of the Afterbirth+ Booster Pack #2, When used, the box will pick up a maximum of 6 items. This allows you to choose between the item that originally spawned and a HP upgrade every time, This effect applies to most items, including those in the shop and devil room. The angel room spawned by The Stairway item also counts, Giving money to a beggar gives a flame orbital, UNLOCK: Unlock this trinket by defeating Mother as Tainted Bethany, Upon entering each new room, this trinket has a chance to copy one of your current familiars, If you have no familiars instead it will spawn either Brother Bobby or Sister Maggy, UNLOCK: Unlock this trinket by defeating Isaac, ?? REPENTANCE - Bob's Brain now has an increased delay before becoming available when entering rooms. He can pick up coins to restore health, Similar to other familiars of this kind, you can hold the drop key to cause him to stand still, If he dies, his corpse turns into a few blue spiders. Searching for the items name is gonna give you the . or The Lamb, it will die instantly, Can also be thrown against a door to open it (Doesn't work against Mega Satan's door). REPENTANCE - Mitre now only has a 33% chance to convert red heart drops into soul hearts (down from 50%). The stationary head is now affected by Isaac's stats and attack modifiers, and the body will spew a controllable fountain of blood shots. * devil pool, devil room pool, devil deal, the lost item pool, cross, upside down, red, black. effect for 10 seconds. Krampus Head) can still spawn, Bible drops caused by the Rosary item are not prevented by this trinket, *, stop, red, circle, line, cross, entry, warning, Causes your familiars to stay closer to each other, Poop in the environment will now explode when destroyed, While held you have an increased chance for Black Poops to spawn, which deal damage to all enemies in the room when destroyed, Gives The Poop active item a chance to spawn a Black Poop too. ?, Satan and The Lamb as Tainted Samson, When taking damage you have a chance to explode and deal 185 damage to all enemies around you (Same damage as a Mr. Mega bomb), UNLOCK: Unlock this trinket by defeating Mother as Tainted Samson, Familiars follow Isaac's exact movements, (similar to how Jacob & Esau work) instead of following loosely like they usually do, Holding the drop button (Ctrl on Steam version) causes them to stop moving, Doesn't affect some familiars with specific movement patterns, e.g. After a few seconds, he will quickly attack each target, chaining higher damage for each enemy it hits, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Judas, When used this will cause 8 poison farts that leave a brown creep behind, and then drop 7 Butt Bombs very quickly, Standing in the creep gives you +1 Damage Up and +1.35 Tears Up, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Blue Baby, For the current room, 14 Dead Birds fly in from off the screen and attack all enemies, dealing low but frequent damage, UNLOCK: Unlock this item by defeating Hush and Boss Rush as Tainted Eve, Isaac gains the Berserk! As such, knowing the details of what an item, a dice room, or a consumable does is essential to success. ?, as they cannot gain red heart containers (except for counting towards the Spun transformation), REPENTANCE - Adrenaline now grants an increasingly higher damage bonus the more empty heart containers Isaac has, * Adderline, pink, syringe, needle, injection, Isaac gains electric tears, which fire 1-2 sparks of electricty in random directions upon hitting any object or enemy, The electricity will chain between nearby enemies, The electricty deals half of your normal tear damage, Tear effects will still apply to your electricty sparks in a lot of cases. - Allows you to hold up to 29 poops, Tainted Eve - Clots created only from red hearts spawn a heart that disappears after 2 seconds when they die, Tainted Samson - Chaining kills adds 3 seconds to the Berserk timer instead of 1, Tainted Lazarus - The inactive character moves alongside you like Esau. It works great. They do not block enemy shots, UNLOCK: Unlock this item by defeating The Beast as Tainted Lilith, Isaac builds rage each time you clear a new room. This deals 1 damage per tick, High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless, Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Cathedral: 1 Angel Room Item + 1 Eternal Heart, Pandora's Box considers XL floors to always be the first floor of a chapter, Alternative floors drop the same stuff e.g. the lost item pool, gold, orange, yellow, cross, pope, hat, A familiar the follows Isaac and fires random tears, Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc, * item room, treasure room, item room pool, purple, Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors, Can be used to open the golden door that appears in the Dark Room or the Chest, Cannot be used to escape the Mom's Foot boss, open angel/devil rooms, or open the door to the Blue Womb floor, UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time, * key master pool, key beggar pool, key judgement pool, item room, treasure room, item room pool, I don't intend in publishing it anywhere when I finish it, but I do want to know opinions and what would you change. in The Chest as Apollyon, Upon entering a room with enemies, spawns a Black Locust that deals quadruple Isaac's damage, applied as two hits of double damage, UNLOCK: Unlock this trinket by defeating The Lamb as Apollyon, At the start of each new hostile room you spawn 2-5 white attack flies, which will target a nearby enemy and deal double your tear damage to it, UNLOCK: Unlock this trinket by defeating Boss Rush as Apollyon, When killing an enemy, you have a very small chance to gain the ability to fly for the rest of the room, UNLOCK: Unlock this trinket by defeating Greedier Mode with Azazel, Stem Cell heals Isaac's red heart containers to 50% each floor, If Isaac already has 50% health or more, it heals half of a heart instead, UNLOCK: Unlock this trinket by defeating Greedier Mode with Samson, Fully recharges your active item at the start of each boss fight, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Zaratus, Gives you the Holy Mantle shield effect at the start of every new floor, which protects you from the next hit of damage you take, Does not recharge until the start of the next floor, Stacks with the effects from Holy Mantle and Blanket, but it does not stack with Holy Card, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by Ep and Mills, Using your active item while holding this trinket will drop it back on a pedestal on the ground, Also after taking damage, you have a very small chance to drop one of your passive items, One-time use active items will be consumed and not dropped, Added as part of the Afterbirth+ Booster Pack #1 and based on the Steam Workshop mod created by MarkusLeben and iguesti, *, yellow, golden, box, block, square, cube, Holding this trinket will cause the Angel mini bosses to drop normal items instead of Key Pieces, Added as part of the Afterbirth+ Booster Pack #2, designed by Edmund McMillen, While held, the last door Isaac went through stays open, allowing him to leave the room even if enemies are in it, This trinket works on boss rooms (except Ultra Greed) and devil rooms containing Krampus, allowing you to exit out mid-fight, UNLOCK: Unlock this trinket by blowing up doors and secret room walls 50 times, *, door, stop, wedge, cheese, wood, brown, hodor, game of thrones, Wylis, After being picked up, a yellow laser chain now flows through Isaac's familiars, Added as part of the Afterbirth+ Booster Pack #4 and based on the Steam Workshop mod created by Strawrat and Aczom, While held, spawns +1 friendly blue fly every time you pick up a coin, Added as part of the Afterbirth+ Booster Pack #5.